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Diclofenac gel ratiopharm preis opramol 10 mg, levonorgestrel 150 μg, and misoprostol 4 mg did not show any efficacy against the most effective contraceptives, and there was no correlation between contraceptive type and effectiveness. The combination of two oral contraceptives, an ethinyl estradiol-containing contraceptive pill given in a dose of 150 μg and levonorgestrel alone in combination showed no efficacy preventing pregnancy. Efficacy of combined hormonal contraceptives. The efficacy of combined hormonal contraceptive was evaluated in a randomised, placebo-controlled, double-blind, parallel group double-blind study in a total of 3115 women between the ages of 18 and 50 years, without history of fertility problems. The study was designed to assess the efficacy of a single oral contraceptive to prevent pregnancy, irrespective of which types were used with the other contraceptive methods. Intervention period. The period of study lasted 18 months. The participants were randomly allocated to 1 of 3 groups according to their contraceptive practices during the 6 months prior to start of the study: (1) no contraception, (2) the use of combined oral contraceptives with ethinyl estradiol 250 μg/day, (3) the use of combined oral contraceptives with ethinyl estradiol 250 μg/day and levonorgestrel 150 μg/day, (4) the use of combined oral contraceptives with ethinyl estradiol 250 μg/day and levonorgestrel 150 μg/day, (5) the use of combined oral contraceptives with ethinyl estradiol 250 μg/day and misoprostol 4 mg/day. The order in which 3 contraceptive methods were used was counterbalanced. Design. This is a crossover, double-blind, parallel group study, with a total of 7 years in-study duration. Women were asked to change their method of contraceptive use for 6 months prior to the start of study. There was one placebo week during the course of study. study lasted for 18 months from the last use of any barrier method before starting the study until start of next study. At each cycle, women were asked about their contraceptive use during preceding study cycles and were asked to provide a baseline period of 28 days to avoid a dropout by the study participants. Main outcome measures. The primary outcome measure was pregnancy rate. Women were asked if they became pregnant during the preceding study cycle. This was defined as the occurrence of pregnancy within 28 days the end of preceding study cycle. If a woman became pregnant while on the study contraceptive, she was deemed never to have been pregnant during the preceding study cycle. The proportion of pregnancies that were prevented was determined by comparing outcomes for women who became pregnant during the preceding study cycle with those who did not. Pregnancy rate by study cycle was compared with pregnancy rate by contraceptive method (no contraception, combined oral contraceptives, contraceptives containing ethinyl estradiol 250 μg/day and no combined use of ethinyl estradiol 250 μg/day and levonorgestrel 150 μg/day). The primary efficacy measure was reduction of pregnancy risk as described in the results section (Figure 2). primary efficacy measures by cycle included pregnancy rate, risk, number of cycles with a pregnancy, and the proportion of cycles with a pregnancy. The proportion of total number cycles that ended in a pregnancy was used to determine if the effectiveness rate was decreased. This proportion would show whether the effectiveness of combination 2 combined is diclofenac available over the counter in canada oral contraceptive methods was similar to the effectiveness of single oral contraceptive in preventing pregnancy (1%). The primary safety measure was occurrence of adverse contraceptive reactions. The primary outcome measure, adverse effect reports, was used by combining the outcomes that had most common adverse events. Interventions. The study included two cycles. first was designed to assess the effectiveness of combined oral contraceptive in preventing pregnancy and was designed to run for 6 months after the last contraception use. second was designed to assess the efficacy of combination 2 combined oral contraceptives in preventing pregnancy and was designed to run for 12 months after the last contraception use. Participants were asked to use the study contraceptive for 12 cycles, with a baseline period of 28 days to allow the participants remain on study. Outcomes. The primary measures were pregnancy rate, risk, number of cycles with a pregnancy, and the proportion of cycles with a pregnancy. The proportion of total number cycles that ended in a pregnancy was used to determine if the effectiveness rate was decreased. Results. In the study period and at end of 24 study cycles, 2105 women (52.5%) became pregnant during the baseline period. pregnancy rate (52.0% per cycle) was similar to that seen in women who did not use the birth control pill. No difference in pregnancy outcome was seen between women who used the combination of oral.

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